The Enzymic Synthesis of Ethanolamine Plasmalogens
نویسندگان
چکیده
منابع مشابه
The enzymic synthesis of ethanolamine plasmalogens.
Enzymic synthesis of ethanolamine plasmalogens from l-14C-hexadecanol in cell-free systems from Ehrlich ascites and Freputial gland tumors of mice is documented. Identiiication of the ethanolamine plasmalogens is based on the preparation and chromatographic behavior of a number of chemical derivatives that take into account all three positions on the glycerol moiety. 14C-Derivatives isolated fr...
متن کاملEvidence that hydrolysis of ethanolamine plasmalogens triggers synthesis of platelet-activating factor via a transacylation reaction.
Addition of 1-O-alk-1'-enyl-2-lyso-sn-glycero-3-phosphoethanolamine (alkenyl-lyso-GPE) to human neutrophil membrane preparations containing 1-O-[3H]hexadecyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (1-O-[3H]alkyl-2-arachidonoyl-GPC) resulted in rapid deacylation of the 1-O-[3H]alkyl-2-arachidonoyl-GPC to 1-O-[3H]alkyl-2-lyso-GPC (lyso-platelet-activating factor, lyso-PAF). When acetyl-CoA...
متن کاملThe enzymatic synthesis of plasmalogens.
Recent work (1) has established that plaamalogenic phosphatides resemble the conventional glycerophosphatides such as phosphatidylcholme (I) very closely in structure, except that one fatty acid ester linkage is replaced in the plasmalogens by an aldehydogenic bond, presumably that of an a,fi-unsaturated ether. The exact position of the aldehydogenic bond is not yet certain. It had been conclud...
متن کاملBiosynthesis of Plasmalogens in Brain 2.1 General Considerations and Distribution of Plasmalogens in Brain Plasmalogens account for the major portion of the ethanolamine glycerophospholipids
Plasmalogens account for the major portion of the ethanolamine glycerophospholipids in the adult human brain (50%), but the brain of newborn babies has low levels (7% of total phospholipids mass) (Horrocks and Sharma, 1982). Levels of ethanolamine plasmalogen (PlsEtn) increase rapidly during the intense period of myelination and ethanolamine glycerophospholipids of myelin sheath contain up to 7...
متن کاملBiosynthesis of phospholipids in Clostridium butyricum: kinetics of synthesis of plasmalogens and the glycerol acetal of ethanolamine plasmalogen.
The biosynthesis of the plasmalogen forms of phosphatidylethanolamine (plasmenylethanolamine) and phosphatidylglycerol (plasmenylglycerol) and of the glycerol acetal of plasmenylethanolamine has been studied in cultures of Clostridium butyricum IFO 3852. When growing cells were pulsed with [32P]orthophosphate, there was a lag of 5 to 7 min between the rapid incorporation of label into the acylp...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1971
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)62176-3